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600-57-7 (11beta-Hydroxyprogesterone)

1

Identification

11beta-Hydroxyprogesterone 11beta-Hydroxyprogesterone
Name 11beta-Hydroxyprogesterone
Formula C21H30O3
MW 330.46
CAS No. 600-57-7
EINECS
Smiles C[[email protected]@]12[[email protected]]3([H])[[email protected]](CCC1=CC(CC2)=O)([H])[[email protected]@]4([H])[[email protected]@](C)([[email protected]@H](C(C)=O)CC4)C[[email protected]@H]3O
Synonyms 11β-Hydroxyprogesterone; (8S,9S,10R,11S,13S,14S,17S)-17-acetyl-11-hydroxy-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
InChI InChI=1S/C21H30O3/c1-12(22)16-6-7-17-15-5-4-13-10-14(23)8-9-20(13,2)19(15)18(24)11-21(16,17)3/h10,15-19,24H,4-9,11H2,1-3H3/t15-,16+,17-,18-,19+,20-,21+/m0/s1
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Introduction

11beta-Hydroxyprogesterone is a potent inhibitors of 11β-Hydroxysteroid dehydrogenase; also activates human mineralocorticoid receptor in COS-7 cells with an ED50 of 10 nM. IC50 & Target: ED50: 10 nM (human mineralocorticoid receptor, COS-7 cell )[1] In Vitro: 11OHP displays agonist mineralocorticoid activity.

Background Information

11beta-Hydroxyprogesterone is a potent inhibitors of <b>11β-Hydroxysteroid dehydrogenase</b>; also activates human mineralocorticoid receptor in COS-7 cells with an <b>ED<sub>50</sub></b> of 10 nM. IC50 & Target: ED50: 10 nM (human mineralocorticoid receptor, COS-7 cell )<sup>[1]</sup> <i><b>In Vitro:</b></i> 11OHP displays agonist mineralocorticoid activity. 11β-hydroxyprogesterone activates the transiently expressed hMR in COS-7 cells in a dose-dependent manner with an ED<sub>50</sub> of 10 nM and stimulates Ams/<sub>sc</sub> in mpkCCD<sub>cl4</sub> cells. Docking 11β-hydroxyprogesterone within the hMR-ligand-binding domain homology model reveals that the agonist activity of 11OHP is caused by contacts between its 11β-hydroxyl group and Asn770<sup>[1]</sup>. <i><b>In Vivo:</b></i> 11β-hydroxyprogesterone causes a significant elevation in blood pressure within 3 days, an effect that persisted throughout the 14-day infusion. 11β-hydroxyprogesterone is potently hypertensinogenic in the rat and that this activity depends on an intact adrenal and at least in part on the activation of mineralocorticoid receptors<sup>[2]</sup>. ......by MedChemexpress Co., Ltd.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance: EBNumber:EB000130109

Storage condition

Solubility

10 mM in DMSO by CHEMSCENE, LLC
10 mM in DMSO by MedChemexpress Co., Ltd.
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Mechanism and Indication

Signaling Pathways Others
Target Others
Research Area Cardiovascular Disease
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
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Safety Data of 11beta-Hydroxyprogesterone

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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
CHEMSCENE, LLC USA
MedChemexpress Co., Ltd. 10mg/USD50(Get quote);50mg/USD110(Get quote) USA
Shanghai Haoyuan Chemexpress Co., Ltd. China
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Related Products

Other Forms of 600-57-7

Name CAS No Formula MW

Recommended Compounds in Others

Name CAS No Formula MW
(R)-(+)-Etomoxir (sodium salt) 828934-41-4 C15H18ClNaO4 320.74
Dictamine 484-29-7 C12H9NO2 199.21
Liothyronine (sodium) 55-06-1 C15H11I3NNaO4 672.96
Afobazole (hydrochloride) 173352-39-1 C15H22ClN3O2S 343.87
FPH2 957485-64-2 C14H16ClN5O2S 353.83
α-Tocopherol (phosphate) 38976-17-9 C29H51O5P 510.69
BAMB-4 891025-25-5 C15H12N2O2 252.27
LDN-27219 312946-37-5 C20H16N4O2S2 408.5
ISO-1 478336-92-4 C12H13NO4 235.24
Aurothioglucose 12192-57-3 C6H11AuO5S 392.18
Oxybenzone 131-57-7 C14H12O3 228.24
ITX3 347323-96-0 C22H17N3OS 371.45
Cardiogreen 3599-32-4 C43H47N2NaO6S2 774.96
Skp2 Inhibitor C1 432001-69-9 C18H13BrN2O4S2 465.34
INH1 313553-47-8 C18H16N2OS 308.4
PF6-AM 1268491-69-5 C33H31BO12 630.4
XEN445 1515856-92-4 C18H17F3N2O3 366.33
Methyl N-ethyl-N-4-(5-nitro-2,1-benzisothiazol-3-yl)azophenyl-alaninate 52239-04-0 C19H19N5O4S 413.45
1,4-bis(Butylamino)anthraquinone 17354-14-2 C22H26N2O2 350.45
CID 797718 370586-05-3 C12H11NO3 217.22

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

11beta-Hydroxyprogesterone

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