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861119-08-6 (A 844606)

1

Identification

A 844606 A 844606
Name A 844606
Formula C20H20N2O2
MW 320.39
CAS No. 861119-08-6
EINECS
Smiles O=C1C2=CC(N3C[[email protected]]4CN(C[[email protected]@H]4C3)C)=CC=C2OC5=CC=CC=C15
Synonyms 2-((3aR,6aR)-5-methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-9H-xanthen-9-one
InChI InChI=1S/C20H20N2O2/c1-21-9-13-11-22(12-14(13)10-21)15-6-7-19-17(8-15)20(23)16-4-2-3-5-18(16)24-19/h2-8,13-14H,9-12H2,1H3/t13-,14-/m1/s1
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Introduction

Background Information

Selective <span class='symbol'>&#945;</span>7 nicotinic acetylcholine receptor (nAChR) partial agonist (EC<sub>50</sub> values are 1.4 and 2.2 <span class='symbol'>&#956;</span>M at human and rat receptors respectively). Displays no measurable effect on <span class='symbol'>&#945;</span>4<span class='symbol'>&#946;</span>2 nAChRs. Stimulates <span class='symbol'>&#945;</span>7 nAChR-induced ERK1/2 phosphorylation in PC12 cells. ......by Tocris Bioscience Inc.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance: EBNumber:EB000123836

Storage condition

Store at -20&deg;C by Tocris Bioscience Inc.

Solubility

Soluble to 5 mM in ethanol with gentle warming by Tocris Bioscience Inc.
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Mechanism and Indication

Signaling Pathways
Target
Research Area
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
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Safety Data of A 844606

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Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
Tocris Bioscience Inc. USA
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Related Products

Other Forms of 861119-08-6

Name CAS No Formula MW

Recommended Compounds in

Name CAS No Formula MW

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

Protocol Reference

Briggs et al (2008) Alpha7 nicotinic acetylcholine receptor agonist properties of tilorone and related tricyclic analogues. Br.J.Pharmacol. 153 1054. PMID: 18157163.

......by Tocris Bioscience Inc.
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More Information

A 844606

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