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107756-30-9 (A 61603 hydrobromide)

1

Identification

A 61603 hydrobromide A 61603 hydrobromide
Name A 61603 hydrobromide
Formula C14H20BrN3O3S
MW 390.3
CAS No. 107756-30-9
EINECS
Smiles OC1=C(NS(=O)(C)=O)C2=C([[email protected]](CCC2)C3=NCCN3)C=C1.Br
Synonyms (S)-N-(5-(4,5-dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)methanesulfonamide hydrobromide
InChI InChI=1S/C14H19N3O3S.BrH/c1-21(19,20)17-13-10-3-2-4-11(14-15-7-8-16-14)9(10)5-6-12(13)18;/h5-6,11,17-18H,2-4,7-8H2,1H3,(H,15,16);1H/t11-;/m0./s1
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Introduction

Background Information

Potent <span class='symbol'>&alpha;</span>-adrenoceptor agonist that is at least 35-fold more potent at <span class='symbol'>&alpha;</span><sub>1A</sub> than at <span class='symbol'>&alpha;</span><sub>1B</sub> or <span class='symbol'>&alpha;</span><sub>1D</sub> sites. Induces dose response increases in spontaneous Ca<sup>2+</sup> transients in rat ventricular myocytes <em>in vitro</em> (EC<sub>50</sub> = 6.9 nmol/L). Also available as part of the <a href='dispprod.php?ItemId=101521'><span class='symbol'>&#945;</span><sub>1</sub>-Adrenoceptor Tocriset&#8482;</a>. ......by Tocris Bioscience Inc.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance: EBNumber:EB000123462

Storage condition

Desiccate at +4&deg;C by Tocris Bioscience Inc.

Solubility

Soluble to 50 mM in water by Tocris Bioscience Inc.
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Mechanism and Indication

Signaling Pathways
Target
Research Area
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
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Safety Data of A 61603 hydrobromide

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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
Shanghai Haoyuan Chemexpress Co., Ltd. China
Tocris Bioscience Inc. USA
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Related Products

Other Forms of 107756-30-9

Name CAS No Formula MW

Recommended Compounds in

Name CAS No Formula MW

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

Protocol Reference

Knepper et al (1995) A-61603, a potent α1-adrenergic receptor agonist, selective for the α1A receptor subtype. J.Pharmacol.Exp.Ther. 274 97. PMID: 7616455.

Meyer et al (1996) Synthesis and in vitro characterisation of N-[5-(4,5-dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]methanesulfonamide and its enantiomers: a novel selective α1A receptor agonist. J.Med.Chem. 39 4116. PMID: 8831777.

Luo et al (2007) Receptor subtype involved in α1A-adrenergic receptor-mediated Ca2+ signaling in cardiomy ......by Tocris Bioscience Inc.

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More Information

A 61603 hydrobromide

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