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80-49-9 (Homatropine methylbromide)

1

Identification

Homatropine methylbromide Homatropine methylbromide
Name Homatropine methylbromide
Formula C17H24BrNO3
MW 370.28
CAS No. 80-49-9
EINECS 201-284-0
Smiles C[N+]1(C)[[email protected]@](CC[[email protected]@]1([H])C2)([H])C[[email protected]@H]2OC(C(O)C3=CC=CC=C3)=O.[Br-]
Synonyms (1R,3r,5S)-3-(2-hydroxy-2-phenylacetoxy)-8,8-dimethyl-8-azabicyclo[3.2.1]octan-8-ium bromide
InChI InChI=1S/C17H24NO3.BrH/c1-18(2)13-8-9-14(18)11-15(10-13)21-17(20)16(19)12-6-4-3-5-7-12;/h3-7,13-16,19H,8-11H2,1-2H3;1H/q+1;/p-1/t13-,14+,15+,16?;
2

Introduction

Background Information

Homatropine Methylbromide is muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively. target: mAChR IC 50: WKY-E(162.5 nM), SHR-E(170.4nM ) In vitro: Homatropine (20 μM) alone produces a dose ratio of 259 in atrium from guinea-pigs. Homatropine (20 μM) produces a dose ratio of only 95.0 when combined with hexamethonium in atrium from guinea-pigs. In vivo: : Pre-treatment with homatropine (20 mg/kg) was comparable with atropine (10 mg/kg) in preventing lethality in this rat model of acute OC poisoning. All rats pre-treated with normal saline, atropine 5 mg/kg, and homatropine 10 mg/kg died. Survival in the homatropine (20 mg/kg) and atropine (10 mg/kg) groups was 30% and 40% respectively. ......by MedChemexpress Co., Ltd.
Homatropine Methylbromide is muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively. ......by Selleck Chemicals LLC
Homatropine methylbromide is a quaternary ammonium muscarinic acetylcholine receptor antagonist belonging to the group of medicines called anti-muscarinics. Homatropine is used to treat duodenal or stomach ulcers or intestine problems. It can be used together with antacids or other medicine in the treatment of peptic ulcer. It may also be used to prevent nausea, vomiting, and motion sickness. ......by Target Molecule Corp.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

Animal Models Sprague-Dawley rats
Dosage 20 mg/kg
Formulation Saline
Administration Intramuscular (IM) injections
Source Selleck Chemicals LLC
4

Physical and Chemical Properties

Appearance: EBNumber:EB000029793

Storage condition

Solubility

DMSO: ≥ 31 mg/mL by CHEMSCENE, LLC
DMSO ≥ 31 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 74 mg/mL (199.84 mM); Water74 mg/mL (199.84 mM); Ethanol10 mg/mL (27.0 mM); In vivo Saline30 mg/mL by Selleck Chemicals LLC
5

Mechanism and Indication

Signaling Pathways Neuronal Signaling GPCR/G Protein
Target mAChR
Research Area Neurological Disease
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Homatropine methylbromide - No Development Reported
Homatropine methylbromide - Launched
7

Safety Data of Homatropine methylbromide

Risk Statements : 20/21/22
Safety Statements : 22-26-36
RTECS : MS9000000
8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
Beijing Merson Pharmaceutical Co., Ltd. China
CHEMSCENE, LLC USA
Carbosynth Limited 1g/USD46();2g/USD74();5g/USD118();10g/USD189();25g/USD302()
MedChemexpress Co., Ltd. 50mg/USD50(In stock);100mg/USD60(In stock);200mg/USD100(In stock);500mg/USD150(In stock) USA
MedKoo Biosciences, Inc. 500mg/USD200();1g/USD250();2g/USD280();5g/USD350();10g/USD450();20g/USD650();50g/USD950();100g/USD1150() USA
Santa Cruz Biotechnology, Inc. 5g/USD174();25g/USD533() USA
Selleck Chemicals LLC 50mg/USD97(In stock);10mM/1mLIn DMSO/USD130(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. China
Sigma-Aldrich, Inc. 250mg/USD326() USA
Target Molecule Corp. 10mg/USD75();50mg/USD225();100mg/USD398();500mg/USD1194() USA
Tokyo Chemical Industry Co., Ltd. 5g/USD105();25g/USD320() Japan
Zhongchang Chemical Co., Ltd. China
10

Related Products

Other Forms of 80-49-9

Name CAS No Formula MW
Homatropine (Bromide) 51-56-9 C16H22BrNO3 356.25
Homatropine 87-00-3 C16H21NO3 275.34

Recommended Compounds in mAChR

Name CAS No Formula MW
Pilocarpine (Hydrochloride) 54-71-7 C11H17ClN2O2 244.72
Imidafenacin 170105-16-5 C20H21N3O 319.4
Flavoxate (hydrochloride) 3717-88-2 C24H26ClNO4 427.92
Homatropine (Bromide) 51-56-9 C16H22BrNO3 356.25
Benztropine (mesylate) 132-17-2 C22H29NO4S 403.54
Otilonium (bromide) 26095-59-0 C29H43BrN2O4 563.57
Arecoline (hydrobromide) 300-08-3 C8H14BrNO2 236.11
Trospium (chloride) 10405-02-4 C25H30ClNO3 427.96
Tiotropium (bromide hydrate) 139404-48-1 C19H24BrNO5S2 490.43
TD-4208 864750-70-9 C35H43N5O4 597.75
Oxybutynin (chloride) 1508-65-2 C22H32ClNO3 393.95
Gallamine Triethiodide 65-29-2 C30H60I3N3O3 891.53
Bethanechol (chloride) 590-63-6 C7H17ClN2O2 196.68
Atropine (sulfate monohydrate) 5908-99-6 C34H50N2O11S 694.83
Methscopolamine (bromide) 155-41-9 C18H24BrNO4 398.29
Irsogladine (maleate) 84504-69-8 C13H11Cl2N5O4 372.16
Irsogladine 57381-26-7 C9H7Cl2N5 256.09
Tropicamide 1508-75-4 C17H20N2O2 284.35
Oxybutynin 5633-20-5 C22H31NO3 357.49
Ipratropium (bromide) 22254-24-6 C20H30BrNO3 412.36

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

12

References

13

More Information

Homatropine methylbromide

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