• Search chemicals, activators, Inhibitors, APIs, intermediates and raw materials.

175340-20-2 (S 18986)

1

Identification

S 18986 S 18986
Name S 18986
Formula C10H12N2O2S
MW 224.28
CAS No. 175340-20-2
EINECS
Smiles O=S1(C2=CC=CC=C2N3[[email protected]@](CCC3)([H])N1)=O
Synonyms (S)-2,3,3a,4-tetrahydro-1H-benzo[e]pyrrolo[2,1-c][1,2,4]thiadiazine 5,5-dioxide
InChI InChI=1S/C10H12N2O2S/c13-15(14)9-5-2-1-4-8(9)12-7-3-6-10(12)11-15/h1-2,4-5,10-11H,3,6-7H2/t10-/m1/s1
2

Introduction

Background Information

Positive allosteric modulator of AMPA receptors. Exhibits cognitive enhancing properties in rodent behavioral models. Brain penetrant. ......by Tocris Bioscience Inc.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance: EBNumber:EB000023921

Storage condition

Store at -20°C by Tocris Bioscience Inc.

Solubility

Soluble to 50 mM in DMSO by Tocris Bioscience Inc.
5

Mechanism and Indication

Signaling Pathways
Target
Research Area
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
S 18986 - No Development Reported
7

Safety Data of S 18986

8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
Shanghai Haoyuan Chemexpress Co., Ltd. China
Tocris Bioscience Inc. USA
10

Related Products

Other Forms of 175340-20-2

Name CAS No Formula MW

Recommended Compounds in

Name CAS No Formula MW

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

12

References

Protocol Reference

Desos et al (1996) Enantioselective synthesis of a pyrrolo-benzothiadiazine derivative S 18986, a new AMPA receptor positive modulator. Bioorg.Med.Chem.Lett. 6 3003.

Lockhart et al (2000) (S)-2,3-dihydro-[3,4]cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide: (S18986-1) a positive modulator of AMPA receptors enhances (S)-AMPA-mediated [3H]noradrenaline release from rat hippocampal and frontal cortex slices. Eur.J.Pharmacol. 401 145. PMID: 10924919.

Bourasset et al (2005) Neuropharmacokinetics of a new α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) modulator, S18986 [(S)-2,3-dihydro-[3,4]cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide], in the rat. Drug Metab.Di ......by Tocris Bioscience Inc.

13

More Information

S 18986

Tags: buy 175340-20-2 IC50 | 175340-20-2 price | 175340-20-2 cost | 175340-20-2 solubility | 175340-20-2 purchase | 175340-20-2 manufacturer | 175340-20-2 research buy | 175340-20-2 order | 175340-20-2 MSDS | 175340-20-2 chemical structure | 175340-20-2 Storage condition | 175340-20-2 molecular weight | 175340-20-2 mw | 175340-20-2 datasheet | 175340-20-2 supplier | 175340-20-2 cell line | 175340-20-2 NMR | 175340-20-2 MS | 175340-20-2 IR | 175340-20-2 solubility | 175340-20-2 Safe information | 175340-20-2 Qc and Spectral Information | 175340-20-2 Clinical Information | 175340-20-2 Clinical Trial | 175340-20-2 Route of Synthesis | 175340-20-2 storage condition | 175340-20-2 diseases and conditions | 175340-20-2 flash point | 175340-20-2 boiling point | 175340-20-2 melting point | 175340-20-2 storage condition | 175340-20-2 brand