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304679-75-2 (S 24795)

1

Identification

S 24795 S 24795
Name S 24795
Formula C14H13BrNO+
MW 291.16
CAS No. 304679-75-2
EINECS
Smiles C[N+]1=C(CC(C2=CC=C(Br)C=C2)=O)C=CC=C1
Synonyms 2-(2-(4-bromophenyl)-2-oxoethyl)-1-methylpyridin-1-ium
InChI InChI=1S/C14H13BrNO/c1-16-9-3-2-4-13(16)10-14(17)11-5-7-12(15)8-6-11/h2-9H,10H2,1H3/q+1
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Introduction

Background Information

Partial agonist of <span class='symbol'>&#945;</span><sub>7</sub> nAChR. Improves mnemonic function in aged mice for the treatment of aging-related memory disturbances. Displays more efficient memory-enhancing effects than <a href='dispprod.php?ItemId=1575'>memantine</a> (Cat. No. 0773) in Alzheimer&#39;s disease mouse models. ......by Tocris Bioscience Inc.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance: EBNumber:EB000023754

Storage condition

Store at +4&deg;C by Tocris Bioscience Inc.

Solubility

Soluble to 10 mM in water with gentle warming and to 100 mM in DMSO by Tocris Bioscience Inc.
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Mechanism and Indication

Signaling Pathways
Target
Research Area
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
S 24795 - No Development Reported
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Safety Data of S 24795

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Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
Shanghai Haoyuan Chemexpress Co., Ltd. China
Tocris Bioscience Inc. USA
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Related Products

Other Forms of 304679-75-2

Name CAS No Formula MW

Recommended Compounds in

Name CAS No Formula MW

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

Protocol Reference

Beracochea et al (2008) Improvement of contextual memory by S 24795 in aged mice: comparison with memantine. Psychopharmacology 196 555. PMID: 18034231.

Lagostena et al (2008) The partial α7 nicotine acetylcholine receptor agonist S 24795 enhances long-term potentiation at CA3-CA1 synapses in the adult mouse hippocampus. Neuropharmacology 54 676. PMID: 18187166.

Marighetto et al (2008) Comparative effects of the α7 nicotinic partial agonist, S 24795, and the cholinesterase inhibitor, donepezil, against aging-related deficits in declarative and working memory in mice. Psychopharmacology. 197 ......by Tocris Bioscience Inc.

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More Information

S 24795

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