• Search chemicals, activators, Inhibitors, APIs, intermediates and raw materials.

1082954-71-9 (A 987306)

1

Identification

A 987306 A 987306
Name A 987306
Formula C18H25N5O
MW 327.42
CAS No. 1082954-71-9
EINECS
Smiles NC1=NC(N2CCNCC2)=C3CCC(O[[email protected]]4([H])[[email protected]@]5([H])CCCC4)=C5C3=N1
Synonyms (7aS,11aS)-4-(piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine
InChI InChI=1S/C18H25N5O/c19-18-21-16-12(17(22-18)23-9-7-20-8-10-23)5-6-14-15(16)11-3-1-2-4-13(11)24-14/h11,13,20H,1-10H2,(H2,19,21,22)/t11-,13+/m1/s1
2

Introduction

Histamine H4R Antagonist

Background Information

Potent histamine H<sub>4</sub> receptor antagonist (pK<sub>i</sub> values are 8.24 and 8.47 in human and rat H<sub>4</sub> receptors respectively). Displays 162-fold, 620-fold, and &gt; 1600-fold selectivity over human H<sub>3</sub>, H<sub>1</sub> and H<sub>2</sub> receptors. Blocks zymosan-induced neutrophil reflux and attenuates thermal hypersensitivity <em>in vivo</em> (ED<sub>50</sub> = 42 <span class='symbol'>&#956;</span>mol/kg, ip). ......by Tocris Bioscience Inc.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance: EBNumber:EB000023345

Storage condition

Store at -20&deg;C by Tocris Bioscience Inc.

Solubility

Soluble to 100 mM in DMSO and to 100 mM in ethanol by Tocris Bioscience Inc.
5

Mechanism and Indication

Signaling Pathways
Target
Research Area
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
A 987306 - No Development Reported
7

Safety Data of A 987306

8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
Shanghai Haoyuan Chemexpress Co., Ltd. China
Tocris Bioscience Inc. USA
10

Related Products

Other Forms of 1082954-71-9

Name CAS No Formula MW

Recommended Compounds in

Name CAS No Formula MW

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

12

References

13

More Information

A 987306

Tags: buy 1082954-71-9 IC50 | 1082954-71-9 price | 1082954-71-9 cost | 1082954-71-9 solubility | 1082954-71-9 purchase | 1082954-71-9 manufacturer | 1082954-71-9 research buy | 1082954-71-9 order | 1082954-71-9 MSDS | 1082954-71-9 chemical structure | 1082954-71-9 Storage condition | 1082954-71-9 molecular weight | 1082954-71-9 mw | 1082954-71-9 datasheet | 1082954-71-9 supplier | 1082954-71-9 cell line | 1082954-71-9 NMR | 1082954-71-9 MS | 1082954-71-9 IR | 1082954-71-9 solubility | 1082954-71-9 Safe information | 1082954-71-9 Qc and Spectral Information | 1082954-71-9 Clinical Information | 1082954-71-9 Clinical Trial | 1082954-71-9 Route of Synthesis | 1082954-71-9 storage condition | 1082954-71-9 diseases and conditions | 1082954-71-9 flash point | 1082954-71-9 boiling point | 1082954-71-9 melting point | 1082954-71-9 storage condition | 1082954-71-9 brand