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60-82-2 (Phloretin)

1

Identification

Phloretin Phloretin
Name Phloretin
Formula C15H14O5
MW 274.27
CAS No. 60-82-2
EINECS 200-488-7
Smiles O=C(CCC1=CC=C(O)C=C1)C2=C(O)C=C(O)C=C2O
Synonyms 2',4',6'-Trihydroxy-3-(4-hydroxyphenyl)propiophenone; 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone; 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one
InChI InChI=1S/C15H14O5/c16-10-4-1-9(2-5-10)3-6-12(18)15-13(19)7-11(17)8-14(15)20/h1-2,4-5,7-8,16-17,19-20H,3,6H2
2

Introduction

Phloretin(NSC 407292; RJC 02792) is a dihydrochalcone, a type of natural phenols.

Background Information

Phloretin(NSC 407292; RJC 02792) is a dihydrochalcone, a type of natural phenols. Phloretin inhibits the active transport of glucose into cells by SGLT1 and SGLT2. IC50 Value: 49 +/- 12 microM [4] Target: SGLT1/2 in vitro: Phlorizin blocks glucose transport across the renal tubule at concentrations in renal blood and tissue in the range of 10-5 to 10-7 M [1]. PT significantly enhanced glycerol release and inhibited the adipogenesis-related transcription factors. PT also promoted phosphorylation of AMP-activated protein kinase and increased activity of adipose triglyceride lipase and hormone-sensitive lipase in 3T3-L1 cells [2]. Phloretin induced obvious cytotoxicity against BEL-7402 cells with IC50 of 89.23 microg/mL. The growth curve demonstrated decreased growth of the cells as phloretin concentration increased [3]. D-glucose-transport activity was observed with a Km for D-glucose of 3.4 +/- 0.2 mM (mean +/- S.E.M.) and was inhibited by cytochalasin B (IC50= 0.44 +/- 0.03 microM), HgCl2 (IC50)= 3.5 +/- 0.5 microM), phloretin (IC50= 49 +/- 12 microM) and phloridzin (IC50= 355 +/- 67 microM) [4]. in vivo: The effect of phloridzin orally doses 5, 10, 20 and 40 mg/kg body weight on diabetes was tested in a streptozotocin-induced rat model of diabetes type 1. From beneficial effect of this compound is significant reduction of blood glucose levels and improve dyslipidemia in diabetic rats [5]. ......by MedChemexpress Co., Ltd.
Phloretin is a dihydrochalcone found in apple tree leaves, which shows beneficial effects on diabetes. ......by Selleck Chemicals LLC
Phloretin is a dihydrochalcone, a type of natural phenols. It can be found in apple tree leaves and the Manchurian apricot. ......by Target Molecule Corp.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:Off-white to pink Solid EBNumber:EB000015345

Storage condition

Solubility

DMSO 55 mg/mL; Water <1 mg/mL; Ethanol 55 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 54 mg/mL (196.88 mM); Ethanol54 mg/mL (196.88 mM); Water<1 mg/mL (<1 mM) by Selleck Chemicals LLC
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Mechanism and Indication

Signaling Pathways Membrane Transporter/Ion Channel
Target SGLT
Research Area Metabolic Disease
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Phloretin - Not Found
Phloretin - No Development Reported
7

Safety Data of Phloretin

Hazard Symbols : Xi
Risk Statements : R36/37/38
Safety Statements : S26;S37/39
WGKGermany : 3
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Spectral Information

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Suppliers List

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Related Products

Other Forms of 60-82-2

Name CAS No Formula MW

Recommended Compounds in SGLT

Name CAS No Formula MW
Dapagliflozin ((2S)-1,2-propanediol, hydrate) 960404-48-2 C24H35ClO9 502.98
Canagliflozin (hemihydrate) 928672-86-0 C24H25FO5S 444.52
Phlorizin 60-81-1 C21H24O10 436.41
LX-4211 1018899-04-1 C21H25ClO5S 424.94
TOFOGLIFLOZIN 1201913-82-7 C22H28O7 404.45
PF-04971729 1210344-57-2 C22H25ClO7 436.88
Empagliflozin 864070-44-0 C23H27ClO7 450.91
CSG 452 903565-83-3 C22H26O6 386.44
Ipragliflozin 761423-87-4 C21H21FO5S 404.45
Dapagliflozin 461432-26-8 C21H25ClO6 408.87
Canagliflozin 842133-18-0 C24H25FO5S 444.52
Bexagliflozin 1118567-05-7 C24H29ClO7 464.94

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

Phloretin

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