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607737-87-1 (A 77-01)

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Identification

A 77-01 A 77-01
Name A 77-01
Formula C18H14N4
MW 286.33
CAS No. 607737-87-1
EINECS
Smiles CC1=CC=CC(C2=NNC=C2C3=CC=NC4=CC=CC=C34)=N1
Synonyms A77-01;A-77-01; 4-(3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl)quinoline
InChI InChI=1S/C18H14N4/c1-12-5-4-8-17(21-12)18-15(11-20-22-18)13-9-10-19-16-7-3-2-6-14(13)16/h2-11H,1H3,(H,20,22)
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Introduction

A 77-01 is a potent inhibitor of TGF-β type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM.

Background Information

A 77-01 is a potent inhibitor of TGF-β type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM. IC50 Value: 25 nM [1] Target: ALK5 A-77-01 is a close analogue of A-83-01(Axon 1421) and has a very similar biological profile of A-83-01. A-83-01 is found to decompose to A-77-01 under certain circumstances and A-77-01 is likely an active component or metabolite of its prodrug A-83-01. ......by MedChemexpress Co., Ltd.
A 77-01 is a potent inhibitor of TGF-(beta) type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM. ......by Target Molecule Corp.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:Light yellow to yellow solid EBNumber:EB000014392

Storage condition

Solubility

DMSO by MedChemexpress Co., Ltd.
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Mechanism and Indication

Signaling Pathways TGF-beta/Smad
Target TGF-β Receptor
Research Area Cancer
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
A 77-01 - Not Found
A 77-01 - No Development Reported
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Safety Data of A 77-01

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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
Apexbio Technology LLC 10mg/USD102(In stock) USA
CHEMSCENE, LLC 5mg/USD120(In stock);10mg/USD180(In stock) USA
Chendu Sinostandards Bio-Tech Co., Ltd 5mg/RMB1710() China
MedChemexpress Co., Ltd. 5mg/USD120(In stock);10mg/USD180(In stock) USA
Santa Cruz Biotechnology, Inc. 5mg/USD186() USA
Shanghai Haoyuan Chemexpress Co., Ltd. 10mg/USD100(In stock);25mg/USD186(In stock) China
Target Molecule Corp. 2mg/USD40();10mg/USD78();50mg/USD235() USA
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Related Products

Other Forms of 607737-87-1

Name CAS No Formula MW

Recommended Compounds in TGF-β Receptor

Name CAS No Formula MW
K 02288 1431985-92-0 C20H20N2O4 352.38
ML347 1062368-49-3 C22H16N4O 352.39
DMH-1 1206711-16-1 C24H20N4O 380.44
LDN-212854 1432597-26-6 C25H22N6 406.48
SB-505124 (hydrochloride) 356559-13-2 C20H22ClN3O2 371.86
SB-505124 694433-59-5 C20H21N3O2 335.4
LY-364947 396129-53-6 C17H12N4 272.3
LDN193189 (Hydrochloride) 1062368-62-0 C25H26Cl4N6 552.33
SD-208 627536-09-8 C17H10ClFN6 352.75
RepSox 446859-33-2 C17H13N5 287.32
LDN193189 1062368-24-4 C25H22N6 406.48
A 83-01 909910-43-6 C25H19N5S 421.52
LY2109761 700874-71-1 C26H27N5O2 441.52
LY2157299 700874-72-2 C22H19N5O 369.42
GW788388 452342-67-5 C25H23N5O2 425.48
SB 525334 356559-20-1 C21H21N5 343.42
SB-431542 301836-41-9 C22H16N4O3 384.39
EW-7197 1352608-82-2 C22H18FN7 399.42
R-268712 879487-87-3 C20H18FN5O 363.39
ITD-1 1099644-42-4 C27H29NO3 415.52

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

A 77-01

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