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848591-90-2 (A 582941)

1

Identification

A 582941 A 582941
Name A 582941
Formula C17H22Cl2N4
MW 353.29
CAS No. 848591-90-2
EINECS
Smiles CN1CC(CN(C2=NN=C(C3=CC=CC=C3)C=C2)C4)C4C1.Cl.Cl
Synonyms 2-methyl-5-(6-phenylpyridazin-3-yl)octahydropyrrolo[3,4-c]pyrrole dihydrochloride
InChI InChI=1S/C17H20N4.2ClH/c1-20-9-14-11-21(12-15(14)10-20)17-8-7-16(18-19-17)13-5-3-2-4-6-13;;/h2-8,14-15H,9-12H2,1H3;2*1H
2

Introduction

Background Information

Selective <span class='symbol'>&#945;</span>7 nAChR partial agonist; exhibits high affinity for both rat and human <span class='symbol'>&#945;</span>7 receptors (K<sub>i</sub> values are 10.8 and 16.7 nM respectively). Displays ~15-fold selectivity for <span class='symbol'>&#945;</span>7 over 5-HT<sub>3</sub> receptors (K<sub>i</sub> = 150 nM for 5-HT<sub>3</sub>). ......by Tocris Bioscience Inc.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance: EBNumber:EB000013197

Storage condition

Desiccate at RT by Tocris Bioscience Inc.

Solubility

Soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl by Tocris Bioscience Inc.
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Mechanism and Indication

Signaling Pathways
Target
Research Area
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
A 582941 - No Development Reported
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Safety Data of A 582941

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Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
Shanghai Haoyuan Chemexpress Co., Ltd. China
Tocris Bioscience Inc. USA
10

Related Products

Other Forms of 848591-90-2

Name CAS No Formula MW
2-Methyl-5-(6-phenylpyridazin-3-yl)octahydropyrrolo[3,4-c]pyrrole 848591-89-9 C17H20N4 280.37

Recommended Compounds in

Name CAS No Formula MW

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

12

References

Protocol Reference

Anderson et al (2008) [3H]A-585539 [(1S,4S)-2,2-dimethyl-5-(6-phenylpyridazin-3-yl)-5-aza-2-azoniabicyclo[2.2.1]heptane], a novel high-affinity α7 neuronal nicotinic receptor agonist: radioligand binding characterization to rat and human brain. J.Pharmacol.Exp.Ther. 324 179. PMID: 17959745.

......by Tocris Bioscience Inc.
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More Information

A 582941

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