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MedKoo Biosciences, Inc.

1235

Basic Information

Company Name:MedKoo Biosciences, Inc.

Business Type:Chemical distributor

Total NO.Employees:

Country/Region:USA

Certificates:

Year Established:

Introduction of MedKoo Biosciences, Inc.

MedKoo is a world leading provider of small molecule anticancer reagents, kinase inhibitors and other pharmaceutical related chemicals. We have operation office located in Research Triangle Park, North Carolina, USA, and have research and manufacturing facilities in China. MedKoo was founded in 2009 by Dr. Qingqi Chen, who obtained a Ph.D. in synthetic/medicinal chemistry from Peking University, and received postdoctoral trainings at Johannes-Kepler University Linz (with Dr. Heinz Falk), University of Nevada Reno (with Dr. David Lightner), and University of British Columbia (with Dr. David Dolphin). Dr. Chen is currently the President and CEO of MedKoo. Prior to joining MedKoo, Dr. Chen was a distinguished professor at the School of Pharmaceutical Sciences of Zhongshan University (Sun Yat-sen University, Guangzhou, China) and a "100-person-plan" professor at the Chinese Academy of Sciences (Beijing, China). Dr. Chen also held senior positions in several pharmaceutical companies in USA, where he made contributions to the R&D of several FDA approved drugs. Dr. Chen has a strong interest in small molecule anticancer drug discovery and has published over 100 papers, submitted 20 patent applications, and authorized or co-authorized 8 books, including "Anticancer Small Molecular Libraries"; "New Drugs in Development for Cancers"; " A Fast Guide to Anti-Cancer Drug Substances, Drug Products and Their Total Synthetic Routes". (all books were written in Chinese, published by Science Press, Beijing). Our team includes most qualified and talented synthetic and medicinal chemists and pharmaceutical marketing experts. They have the experience to manage the complex activities and tight time lines required for pharmaceutical projects. MedKoo is capable to provide qualified products and services at a very competitive price. Medkoo offers products and service from discovery and early medicinal chemistry to multiple kilogram scale synthesis Our success is due to our competitive pricing, our firmly commitment to customer service and to the talent and experience of our scientists, most of whom hold doctorates in chemistry, pharmaceuticals and chemical engineers. Our services include: Research services: including all areas of medicinal chemistry research, custom organic synthesis, synthetic route optimization, synthetic process development, formulation development, bioanalytical services, molecule sourcing services, and molecule distributing services. About the name "MedKoo" MedKoo was originated from the combination of two words: "Medicine" and "Koo". In Chinese, "Koo" means big stockroom or warehouse. MedKoo literally means a comprehensive collection of medicinal chemicals.

Web: www.medkoo.com TEL:919-279-0682 Fax:919-980-4831 Email:[email protected]

Products of MedKoo Biosciences, Inc.

  • Chemical Name: Defactinib
    CAS No.: 1073154-85-4 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: VS-6063;VS6063;VS 6063; N-m... Quality Control & MSDS Files:
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  • Chemical Name: GNE-9605
    CAS No.: 1536200-31-3 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: GNE 9605;GNE9605;N2-(5-chlo... Quality Control & MSDS Files:
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  • Chemical Name: AGN 194310
    CAS No.: 229961-45-9 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: AGN194310;AGN-194310;VTP194... Quality Control & MSDS Files:
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    AGN 194310(VTP-194310) is a potent and selective pan-RARs agonist with Kd values of 3/2/5 nM for RARα/β/γ respectively. IC50 value: 3/2/5 nM (Kd for RARα/β/γ) [1][2] Target: RARs agonist in vitro: A high affinity pan-RAR antagonist (AGN194310, K(d) for binding to RARs = 2-5 nM) inhibited colony formation (by 50%) by all three lines ...

  • Chemical Name: Talabostat
    CAS No.: 150080-09-4 Purity: Appearances:
    Brand: Synonyms: ; IUPAC/Chemical name: (R)-... Quality Control & MSDS Files:
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    Talabostat mesylate is the orally bioavailable mesylate salt of an amino boronic dipeptide with antineoplastic and hematopoiesis- stimulating activities. By cleaving N-terminal Xaa-Pro or Xaa-Ala residues, talabostat inhibits dipeptidyl peptidases, such as fibroblast activation protein (FAP), resulting in the stimulation of cytokine an...

  • Chemical Name: DMH-1
    CAS No.: 1206711-16-1 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: DMH1;DMH 1; 4-(6-(4-isoprop... Quality Control & MSDS Files:
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    DMH-1 is a potent and selective BMP inhibitor with IC50s of 27/107.9/<5 nM for ALK1/2/3 respectively; inactive on ALK5, BMPR2, AMPK and VEGFR2. IC50 value: 27/107.9/<5 nM(ALK1/2/3) [1] Target: ALK inhibitor DMH-1 shows the most selectivity within these three compounds(LDN-193189, DMH-1 and dorsomorphin) [1].

  • Chemical Name: CB-839
    CAS No.: 1439399-58-2 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: 2-(pyridin-2-yl)-N-(5-(4-(6... Quality Control & MSDS Files:
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  • Chemical Name: Satraplatin
    CAS No.: 129580-63-8 Purity: Appearances:
    Brand: Synonyms: ; IUPAC/Chemical name: (OC-... Quality Control & MSDS Files:
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    Shelf life: >2 years if stored properly Drug formulation:

  • Chemical Name: Thiotepa
    CAS No.: 52-24-4 Purity: Appearances:
    Brand: Synonyms: ; IUPAC/Chemical name: tri(... Quality Control & MSDS Files:
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    Shelf life: >2 years if stored properly Drug formulation:

  • Chemical Name: GDC-0834
    CAS No.: 1133432-46-8 Purity: Appearances:
    Brand: Synonyms: GDC-0834; GDC0834; GDC 0834... Quality Control & MSDS Files:
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    GDC-0834 is a potent and selective inhibitor of Bruton's tyrosine kinase (BTK), investigated as a potential treatment for rheumatoid arthritis. In vitro metabolite identification studies in hepatocytes revealed predominant formation of an inactive metabolite (M1) via amide hydrolysis in human. Shelf life: >2 years if stored properly Dr...

  • Chemical Name: GBR 12935 (dihydrochloride)
    CAS No.: 67469-81-2 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: GBR12935 dihydrochloride;GB... Quality Control & MSDS Files:
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    GBR 12935 2Hcl is a potent, and selective dopamine reuptake inhibitor. IC50 value: Target: dopamine reuptake inhibitor in vitro: The calculated Kd of [3H]GBR-12935 binding to CYP2D6 was 42.2 nM, indicating that GBR-12935 has a high affinity for CYP2D6.

  • Chemical Name: CP-640186 (hydrochloride)
    CAS No.: 591778-70-0 Purity: Appearances: Pink to red Solid
    Brand: Synonyms: CP640186 hydrochloride;CP 6... Quality Control & MSDS Files:
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    CP-640186 Hcl is an isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively; with improved metabolic stability vs CP-610431. IC50 value: 53 nM/61 nM (rat liver ACC1/skeletal muscle ACC2) [1] Target: acetyl-CoA carboxylase in vitro: CP-6401...

  • Chemical Name: PI-3065
    CAS No.: 955977-50-1 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: PI3065;PI 3065; 4-(6-((4-(c... Quality Control & MSDS Files:
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    PI-3065 is a novel potent and selective PI3K p110δ inhibitor with IC50 of 15 nM; exhibits > 100 fold selectivity against p110α, p110β, p110γ, DNA-PK and mTOR. IC50 value: 15 nM Target: p110δ

  • Chemical Name: PF-06463922
    CAS No.: 1454846-35-5 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: PF 06463922;PF 06463922; Quality Control & MSDS Files:
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  • Chemical Name: Nrf1-activator-1
    CAS No.: 1474034-05-3 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: N-((4aS,6aR,6bS,8aR,12aS,14... Quality Control & MSDS Files:
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    Nrf1-activator-1 is a potent Nrf1/ARE activator; Neuroprotective effect. IC50 value: Target: Nrf1/ARE activator For more information 1, Methods of preparation and use of A-ring epoxidized triterpenoid-based anti-inflammation modulators By Anderson, Eric; Bender, Christopher F.; Jiang, Xin; Liu, Xiaofeng; Sun, Haizhou; Visnick, Me...

  • Chemical Name: PFK-015
    CAS No.: 4382-63-2 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: PFK015;PFK 015; (E)-1-(pyri... Quality Control & MSDS Files:
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    PFK-015 is an effective inhibitor of PFKFB3 with IC50 of 110 nM (recombinant PFKFB3) and inhibits PFKFB3 activity in cancer cells with IC50 of 20 nM. IC50 value: 110 nM (recombinant PFKFB3)[1] Target: PFKFB3 PFK-015 possesses compelling in vitro properties, has satisfactory PK properties in rodents, and suppresses tumor glucose met...

  • Chemical Name: CH5164840
    CAS No.: 1052645-73-4 Purity: >98% Appearances: white solid powder
    Brand: Synonyms: CH-5164840;CH 5164840; Quality Control & MSDS Files:
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    CH5164840 is a potent and selective HSP90 inhibitor. CH5164840 showed remarkable antitumor activity against NSCLC cell lines and xenograft models. CH5164840 has potent antitumor activity and is highly effective in combination with erlotinib against NSCLC tumors with EGFR overexpression and mutations. (03/26/2014) Shelf life: >2 years i...

  • Chemical Name: VER-49009
    CAS No.: 558640-51-0 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: VER49009;VER 49009;CCT12939... Quality Control & MSDS Files:
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    VER-49009 is a pyrazole compound that inhibits Hsp90 with an IC50 value of 47 nM. IC50 value: 47 nM Target: Hsp90 VER-49009 produces a cellular antiproliferative GI50 value of 685 nM when tested against a human cancer cell line panel.