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A 922500

(CAS: 959122-11-3)

Suppliers of A 922500

Company Name Email Tel Country
CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: >98% Brand:

Price and Availability: USD105/5mg (In stock) USD147/10mg (In stock) USD469/50mg (In stock) USD700/100mg (In stock)

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: >98% Brand:

Price and Availability: USD105/5mg (In stock) USD147/10mg (In stock) USD469/50mg (In stock) USD700/100mg (In stock)
Quality Control & MSDS Files: HNMR LCMS MSDS

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: >98% Brand:

Price and Availability: USD150/5mg (In stock) USD210/10mg (In stock) USD260/10mM/1mLIn DMSO (In stock) USD670/50mg (In stock) USD1780/200mg (In stock)
Quality Control & MSDS Files: HPLC HPLC

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: >98% Brand:

Price and Availability: USD105/5mg (In stock) USD147/10mg (In stock) USD469/50mg (In stock) USD700/100mg (In stock)

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD76/5mg () USD548/100mg ()

Tocris Bioscience Inc. market[email protected] +1 (636) 207-7651 USA

Fax: +1 (636) 207-7683Purity: #98 % Brand: Tocris

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Background Information of A 922500

A 922500 is a potent, selective, and orally bioavailable DGAT-1 inhibitor with IC50 values of 7 nM and 24 nM for human and mouse DGAT-1 respectively. IC50 Value: 7 nM(human DGAT-1); 24 nM(DGAT-1) [1] Target: DGAT-1 in vitro: A 922500 potently inhibits huDGAT-1 and mseDGAT-1 [1].

Solubility of A 922500

Solubility Sources
DMSO 86 mg/ml; Water < 1 mg/ml MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 86 mg/mL (200.7 mM); Water<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM); In vivo 15% Captisol20 mg/mL Selleck Chemicals LLC
Soluble to 50 mM in DMSO Tocris Bioscience Inc.

Storage Condition of A 922500

Storage Condition Sources
Desiccate at +4&deg;C Tocris Bioscience Inc.

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [LCMS] MedChemexpress Co., Ltd.
[HPLC] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways Metabolic Enzyme/Protease
Target DGAT
Research Area Metabolic Disease
Indications

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
A 922500 - Discovery
A 922500 - No Development Reported

Chemical Information

M.Wt Formula CAS No. Synonyms
428.48 C26H24N2O4 959122-11-3 DGAT-1 Inhibitor 4a;A-922500; A922500; (1R,2R)-2-(4'-(3-phenylureido)-[1,1'-biphenyl]-4-carbonyl)cyclopentanecarboxylic acid

Structure Information of A 922500

Smiles O=C(NC1=CC=C(C2=CC=C(C([[email protected]@H]3CCC[[email protected]]3C(O)=O)=O)C=C2)C=C1)NC4=CC=CC=C4
InChI InChI=1S/C26H24N2O4/c29-24(22-7-4-8-23(22)25(30)31)19-11-9-17(10-12-19)18-13-15-21(16-14-18)28-26(32)27-20-5-2-1-3-6-20/h1-3,5-6,9-16,22-23H,4,7-8H2,(H,30,31)(H2,27,28,32)/t22-,23-/m1/s1

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Chemical and Physical Properties

Appearance:White to off-white solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:
Density:1.323 Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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