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X-376

(CAS: 1365267-27-1)

Suppliers of X-376

Company Name Email Tel Country
CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: >98% Brand: Chemscene

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: >98% Brand: MedChemExpress

Price and Availability: USD140/2mg (In stock) USD280/5mg (In stock) USD450/10mg (In stock) USD950/25mg (In stock) USD1500/50mg (In stock) USD2400/100mg (In stock)
Quality Control & MSDS Files: HNMR NP-HPLC MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

Fax: 919-980-4831Purity: Brand:

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: >98% Brand:

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Background Information of X-376

Solubility of X-376

Solubility Sources
DMSO: ≥ 37 mg/mL CHEMSCENE, LLC
DMSO: ≥ 37 mg/mL MedChemexpress Co., Ltd.

Storage Condition of X-376

Storage Condition Sources

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [NP-HPLC] MedChemexpress Co., Ltd.

Mechanism and Indications

Signaling Pathways Protein Tyrosine Kinase/RTK
Target ALK
Research Area Cancer
Indications

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
X-376 - Phase 1 Clinical
X-376 - Phase 3

Chemical Information

M.Wt Formula CAS No. Synonyms
547.41 C25H25Cl2FN6O3 1365267-27-1 (R)-6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-N-(4-(4-methylpiperazine-1-carbonyl)phenyl)pyridazine-3-carboxamide

Structure Information of X-376

Smiles O=C(C1=NN=C(N)C(O[[email protected]@H](C2=C(Cl)C=CC(F)=C2Cl)C)=C1)NC3=CC=C(C(N4CCN(C)CC4)=O)C=C3
InChI InChI=1S/C25H25Cl2FN6O3/c1-14(21-17(26)7-8-18(28)22(21)27)37-20-13-19(31-32-23(20)29)24(35)30-16-5-3-15(4-6-16)25(36)34-11-9-33(2)10-12-34/h3-8,13-14H,9-12H2,1-2H3,(H2,29,32)(H,30,35)/t14-/m1/s1

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Other Form Products of X-376

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PF-06463922 1454846-35-5 C21H19FN6O2 12
CEP-37440 1391712-60-9 C30H38ClN7O3 8
HG-14-10-04 1356962-34-9 C29H34ClN7O 4
LDK378 (dihydrochloride) 1380575-43-8 C28H38Cl3N5O3S 6
LDK378 1032900-25-6 C28H36ClN5O3S 10
AZD-3463 1356962-20-3 C24H25ClN6O 11
CEP-28122 1022958-60-6 C28H35ClN6O3 8
AP26113 1197958-12-5 C26H34ClN6O2P 11
Crizotinib (hydrochloride) 1415560-69-8 C21H23Cl3FN5O 3
ALK inhibitor 2 761438-38-4 C23H28ClN7O3S 5
ALK inhibitor 1 761436-81-1 C23H28BrN7O3S 4
1-Piperidineacetamide, 4-[3-methoxy-4-[[7-(2-methoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]phenyl]- 1233145-49-7 C27H30N6O3 1
ASP3026 1097917-15-1 C29H40N8O3S 13
GSK1838705A 1116235-97-2 C27H29FN8O3 8
A 83-01 909910-43-6 C25H19N5S 6
CH5424802 1256580-46-7 C30H34N4O2 9
Crizotinib 877399-52-5 C21H22Cl2FN5O 19
NVP-TAE 684 761439-42-3 C30H40ClN7O3S 8
Belizatinib 1357920-84-3 C33H44FN5O3 2
Brigatinib 1197953-54-0 C29H39ClN7O2P 4

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Chemical and Physical Properties

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Vapour: EINECS:
Optical Rotation: alpha:

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